Drug For Depression
 There are various drugs available on the market for the treatment of depression. Do you know which one is right for you? Drugfordepression.com will help you understand the real meaning of depression and how you can recognize it. Also, it will help you understand the seriousness of depression and its causes. You can browse through the “Guide” to understand the various drugs available on the market and their kinds. You can even adopt the various exclusive techniques for coming out of depression after reading through the “Help” tab.
Recognizing depression is the first step. We think Drugfordepression.com can help you give depression a tough fight.
History of Depression Drugs:
Depression drugs became prescriptions in the 1950s. Although the exact purpose of the drugs was not known at that time. Research continued and newer drugs were developed. The first compound to be patented, in 1971, was Zimelidine. The first released clinically was Indalpine. Fluoxetine was approved for commercial use by the Food and Drug administration of the United States in 1988, becoming the first blockbuster SSRI. It was in the late 1980s that anti depressants were acknowledged for their sole purpose and sales of these drugs started catching up. Newer drugs such as SNRIs and NRIs were made commercial and companies like Glaxosmithkline started manufacturing these drugs on a larger basis.
Various Types of Depression Drugs:
Selective serotonin reuptake inhibitors (SSRIs):
SSRIs are a family of antidepressants considered to be the current standard of drug treatment. SSRIs are said to work by preventing the reuptake of serotonin by the presynaptic neuron, thus maintaining higher levels of serotonin in the synapse. This family of drugs includes Celexa, Lexapro, Prozac and Zoloft.
Serotonin-norepinephrine reuptake inhibitors (SNRIs):
SNRIs are a newer form of antidepressant that work on both norepinephrine and 5-HT. They typically have similar side effects to the SSRIs, although there may be a withdrawal syndrome on discontinuation that may necessitate dosage tapering. These include Effexor, Ixel and Pristiq.
Noradrenergic and specific serotonergic antidepressants (NaSSAs):
NaSSAs form a newer class of antidepressants which purportedly work to increase noradrenaline and serotonin neurotransmission by blocking certain serotonin receptors. Side effects may include drowsiness, increased appetite, and weight gain. Examples include tolvon and zispin.
Norepinephrine (noradrenaline) reuptake inhibitors (NRIs):
NRIs act via noradrenaline. NRIs are thought to have a positive effect on concentration and motivation in particular. These include some famous drugs like mazanor, edronax and vivalan.
Norepinephrine-dopamine reuptake inhibitors (NDRIs):
NDRIs inhibit the neuronal reuptake of dopamine and noradrenaline. These include wellbutrin and zyban.
Tricyclic antidepressants (TCAs):
TCAs are the oldest class of antidepressant drugs. They are used less commonly now due to the development of more selective and safer drugs. Side effects include increased drowsiness, dry mouth, constipation, urinary retention, blurred vision, dizziness, confusion, and sexual dysfunction. These drugs are often lethal in overdoses, as they may cause a fatal arrhythmia. These include Elavil, tofranil, pamelor and vivactil.
Monoamine oxidase inhibitor (MAOIs):
MAOIs may be used if other antidepressant medications are ineffective. MAOIs can be as effective as tricyclic antidepressants, although they can have a higher incidence of dangerous side effects. These include marplan, nardil and parnate.
Augmenter drugs:
Some antidepressants have been found to work more effectively in some patients when used in combination with another drug. Such "augmenter" drugs include Buspirone and trazodone.
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